Mitochondria--a nexus for aging, calorie restriction, and sirtuins?
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 18243090.
- Also identified by DOI 10.1016/j.cell.2008.01.007 and PMC identifier 2680180.
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Abstract
Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.
Medical subject headings
- Aging
- Caloric Restriction
- Mitochondria
- Sirtuins