A notch sweeter.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18243091.
- Also identified by DOI 10.1016/j.cell.2008.01.005.
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Abstract
Notch is a key signaling protein mediating cell-fate decisions during development. In this issue, Acar et al. (2008) describe a new gene called rumi that is required for Notch signaling in Drosophila. This gene encodes an O-glucosyltransferase that attaches glucose sugars to serine residues in the multiple EGF domains of the extracellular region of Notch. This modification by Rumi likely influences Notch folding and trafficking.
Medical subject headings
- Drosophila Proteins
- Glucosyltransferases
- Receptors, Notch
- Signal Transduction