A new look at cytokine signaling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18243092.
- Also identified by DOI 10.1016/j.cell.2008.01.006.
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Abstract
Signal transduction is initiated when a cytokine binds to the extracellular domains of its receptors, bringing them together and triggering a complicated sequence of events inside the cell. In this issue, LaPorte et al. (2008) present crystal structures of three signaling complexes of the cytokines interleukin-4 and interleukin-13 with their receptors, showing how events taking place outside the cell may affect the specificity of signal transduction.
Medical subject headings
- Cytokines
- Receptors, Cytokine
- Signal Transduction