Mps1 checks up on chromosome attachment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18243093.
- Also identified by DOI 10.1016/j.cell.2008.01.008.
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Abstract
The protein kinase Mps1, a crucial regulator of the spindle-assembly checkpoint, now turns out to be essential for correcting errors in chromosome attachment (Jelluma et al., 2008). Mps1 exerts this effect by regulating the activity of the Aurora B kinase through phosphorylation of its partner protein Borealin.
Medical subject headings
- Cell Cycle Proteins
- Chromosomes, Human
- Protein Serine-Threonine Kinases
- Spindle Apparatus