Metabotropic glutamate receptor agonists for schizophrenia.

Harrison, Paul J · Br J Psychiatry · 2008

editorial · Level V

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Abstract

A drug acting at metabotropic glutamate receptors has recently been reported to be an effective antipsychotic, breaking the rule that only dopamine receptor-blocking drugs have this property. The finding complements accumulating evidence that glutamatergic abnormalities are important in the pathophysiology of schizophrenia.

Medical subject headings