Human leukocyte antigen-G and cancer immunoediting.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18245459.
- Also identified by DOI 10.1158/0008-5472.CAN-07-2704.
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Abstract
Immunosurveillance is an extrinsic mechanism of cancer suppression that eliminates nascent tumors. However, the selection imposed by immunosurveillance can drive tumor evolution and the emergence of clinically apparent neoplasms. Mechanisms of immune escape acquired by less immunogenic variants during this process, termed immunoediting, may contribute significantly to malignant progression. In this review, we summarize the evidence that up-regulation of the nonclassic human leukocyte antigen (HLA) class I molecule HLA-G in tumor cells plays an important role in cancer and immune escape.
Medical subject headings
- HLA Antigens
- Histocompatibility Antigens Class I
- Neoplasms