More chores for TOR: de novo ceramide synthesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18249168.
- Also identified by DOI 10.1016/j.cmet.2008.01.002.
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Abstract
In this issue of Cell Metabolism, Aronova et al. (2008) show that target of rapamycin complex 2 (TORC2) controls de novo ceramide synthesis in yeast by regulating the activity of ceramide synthase. This work may provide insight into how chemotherapeutic drugs increase de novo ceramide synthesis and promote cell death in humans.
Medical subject headings
- Cell Cycle Proteins
- Ceramides
- Phosphatidylinositol 3-Kinases
- Saccharomyces cerevisiae Proteins