Phosphatases at the heart of FoxO metabolic control.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18249169.
- Also identified by DOI 10.1016/j.cmet.2008.01.004.
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Abstract
FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A.
Medical subject headings
- Cardiomegaly
- Forkhead Transcription Factors
- Metabolism
- Phosphoric Monoester Hydrolases