Interaction of nanoparticles with lipid membrane.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18254602.
- Also identified by DOI 10.1021/nl080080l.
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Abstract
A nanoscale range of surface feature curvatures where lipid membranes lose integrity and form pores has been found experimentally. The pores were experimentally observed in the l-alpha-dimyristoyl phosphatidylcholine membrane around 1.2-22 nm polar nanoparticles deposited on mica surface. Lipid bilayer envelops or closely follows surface features with the curvatures outside of that region. This finding provides essential information for the understanding of nanoparticle-lipid membrane interaction, cytotoxicity, preparation of biomolecular templates and supported lipid membranes on rough and patterned surfaces.
Medical subject headings
- Lipid Bilayers
- Nanoparticles