Clearing the path for germ cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18267065.
- Also identified by DOI 10.1016/j.cell.2008.01.023.
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Abstract
The chemokine SDF-1a and its receptor CXCR4b guide germ cell migration in zebrafish by activating downstream signaling events. Boldajipour et al. (2008) now report that a second SDF-1a receptor, CXCR7, is also required for guided migration but does not function as a signaling receptor, and instead sequesters SDF-1a. These results highlight the importance of ligand clearance during guided cell migration.
Medical subject headings
- Cell Movement
- Germ Cells