Secreting tumor suppression.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18267066.
- Also identified by DOI 10.1016/j.cell.2008.01.022 and PMC identifier 3285252.
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Abstract
Cellular senescence limits the proliferative capacity of damaged cells and thereby acts as an intrinsic mechanism of tumor suppression. In this issue, Wajapeyee et al. (2008) identify insulin growth factor binding protein 7 (IGFBP7) as a secreted factor that mediates senescence induced by oncogenic BRAF in normal melanocytes. In addition, IGFBP7 triggers apoptosis in cells that have progressed to melanoma, suggesting a new approach for melanoma treatment.
Medical subject headings
- Apoptosis
- Cellular Senescence
- Insulin-Like Growth Factor Binding Proteins
- Proto-Oncogene Proteins B-raf