Shared principles in NF-kappaB signaling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18267068.
- Also identified by DOI 10.1016/j.cell.2008.01.020.
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Abstract
The transcription factor NF-kappaB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-kappaB, and the large number of genes regulated by NF-kappaB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation.
Medical subject headings
- NF-kappa B
- Signal Transduction