Nephrin AKTs on actin: The slit diaphragm-actin cytoskeleton signaling network expands.
editorial · Level V
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- Record sourced from PubMed, PMID 18274541.
- Also identified by DOI 10.1038/sj.ki.5002741.
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Abstract
Regulation and maintenance of the actin cytoskeleton of podocytes has emerged as a critical process for preserving glomerular permselectivity. Signaling through nephrin, a crucial component of the slit diaphragm, can lead to rearrangement of the actin cytoskeleton. Zhu et al. identify phosphoinositide 3-kinase-dependent activation of Akt and Rac as mediators of nephrin-induced actin reorganization, expanding the signaling network linking two of the podocyte's unique structures, its actin cytoskeleton and the slit diaphragm.
Medical subject headings
- Actins
- Cell Adhesion
- Cytoskeleton
- Membrane Proteins
- Podocytes