Marked differences in differentiation propensity among human embryonic stem cell lines.
basic_science · Level V
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- Record sourced from PubMed, PMID 18278034.
- Also identified by DOI 10.1038/nbt1383.
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Abstract
The differentiation potential of 17 human embryonic stem (hES) cell lines was compared. Some lines exhibit a marked propensity to differentiate into specific lineages, often with >100-fold differences in lineage-specific gene expression. For example, HUES 8 is best for pancreatic differentiation and HUES 3 for cardiomyocyte generation. These non-trivial differences in developmental potential among hES cell lines point to the importance of screening and deriving lines for lineage-specific differentiation.
Medical subject headings
- Cell Differentiation
- Embryonic Stem Cells