Perivascular nitric oxide gradients normalize tumor vasculature.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18278052.
- Also identified by DOI 10.1038/nm1730.
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Abstract
Normalization of tumor vasculature is an emerging strategy to improve cytotoxic therapies. Here we show that eliminating nitric oxide (NO) production from tumor cells via neuronal NO synthase silencing or inhibition establishes perivascular gradients of NO in human glioma xenografts in mice and normalizes the tumor vasculature, resulting in improved tumor oxygenation and response to radiation treatment. Creation of perivascular NO gradients may be an effective strategy for normalizing abnormal vasculature.
Medical subject headings
- Glioma
- Nitric Oxide