Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18278811.
- Also identified by DOI 10.1002/cncr.23318.
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Abstract
New therapeutic strategies are needed to improve treatment outcomes in men with hormone-refractory prostate cancer. A better understanding of the molecular mechanisms of cell death in response to therapeutic strategies will help avoid ineffective treatment regimens and provide a molecular basis for new therapeutic modalities targeting apoptosis-resistant forms of prostate cancer. In this review, the authors focused on the established aberrations of apoptosis in hormone-refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance.
Medical subject headings
- Antineoplastic Agents, Hormonal
- Apoptosis
- Drug Resistance, Neoplasm
- Prostatic Neoplasms