Hepatitis E virus and chronic hepatitis in organ-transplant recipients.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 18287603.
- Also identified by DOI 10.1056/NEJMoa0706992.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.
Medical subject headings
- Hepatitis E
- Hepatitis E virus
- Hepatitis, Chronic
- Kidney Transplantation
- Liver Transplantation