Beyond gastric emptying: a "toxic" lesson about gastroparesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18289204.
- Also identified by DOI 10.1111/j.1572-0241.2007.01672.x.
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Abstract
The first published controlled trial of intrapyloric botulinum toxin for gastroparesis failed to demonstrate a significant effect of treatment on symptoms, despite an improvement in gastric emptying. In this editorial, I discuss the limitations and implications of this study, with particular emphasis on what the use of botulinum toxin can teach us about the pathophysiology of gastroparesis and other gastrointestinal smooth muscle disorders.
Medical subject headings
- Botulinum Toxins, Type A
- Gastric Emptying
- Gastroparesis
- Neuromuscular Agents