The invention and development of enflurane, isoflurane, sevoflurane, and desflurane.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18292690.
- Also identified by DOI 10.1097/ALN.0b013e31816499cc.
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Abstract
Thirty-six halogenated Me Et ethers have been synthesized for evaluation as volatile anesthetics. Eleven of the ethers were too unstable to test, and, of the remaining 25, 13 had promising anesthetic properties in mice and are suitable for study in larger animals. Those ethers having one H with at least 2 halogens other than F or 2 or more H with at least one Br or Cl were the best anesthetics.
Medical subject headings
- Enflurane
- Isoflurane
- Methyl Ethers