Hepatic glucose sensing: does flux matter?
basic_science · Level V
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- Record sourced from PubMed, PMID 18292804.
- Also identified by DOI 10.1172/JCI35137 and PMC identifier 2248806.
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Abstract
In this issue of the JCI, Denechaud et al. report studies investigating the role of the liver X receptors (LXRs) LXRalpha and LXRbeta in carbohydrate sensing by the liver (see the related article beginning on page 956). The results of this study, which utilized LXRalpha/beta double-KO mice, strongly contradict a recent Nature report that proposed that LXRalpha/beta sense glucose independent of metabolic flux. The reported findings further support a key role for the carbohydrate-responsive element-binding protein (ChREBP) in the regulation of lipogenic genes by glucose and dietary carbohydrates.
Medical subject headings
- DNA-Binding Proteins
- Gene Expression Regulation
- Glucose
- Liver
- Nuclear Proteins
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors