Capturing pluripotency.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18295569.
- Also identified by DOI 10.1016/j.cell.2008.02.006 and PMC identifier 2427053.
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Abstract
In this Essay, we argue that pluripotent epiblast founder cells in the embryo and embryonic stem (ES) cells in culture represent the ground state for a mammalian cell, signified by freedom from developmental specification or epigenetic restriction and capacity for autonomous self-replication. We speculate that cell-to-cell variation may be integral to the ES cell condition, safe-guarding self-renewal while continually presenting opportunities for lineage specification.
Medical subject headings
- Embryo, Mammalian
- Embryonic Stem Cells
- Pluripotent Stem Cells