Association of the asporin D14 allele with lumbar-disc degeneration in Asians.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 18304494.
- Also identified by DOI 10.1016/j.ajhg.2007.12.017 and PMC identifier 2427233.
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Abstract
Lumbar-disc degeneration (LDD) is a polygenic disease. Susceptibility genes reported so far are mainly extracellular matrix proteins. D14 allele of asporin (ASPN) is associated with osteoarthritis (OA). Candidate-gene association studies showed that the D14 allele is also significantly associated with LDD in Chinese and Japanese individuals. Meta-analysis showed that individuals harboring a D14 allele had higher risk with a summary odds ratio of 1.70 (p = 0.000013). ASPN expression in vertebral discs increased with age and degeneration. Our results indicate ASPN is a LDD gene in Asians, and common risk factors may be considered for OA and LDD.
Medical subject headings
- Adolescent
- Adult
- Alleles
- Asian People
- Asian People/genetics
- Aspartic Acid
- Aspartic Acid/chemistry
- Aspartic Acid/genetics
- Extracellular Matrix Proteins
- Extracellular Matrix Proteins/chemistry
- Extracellular Matrix Proteins/genetics
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Intervertebral Disc
- Lumbar Vertebrae
- Male
- Middle Aged
- Osteoarthritis
- Osteoarthritis/genetics
- Osteochondritis
- Osteochondritis/genetics
- Polymorphism, Genetic
- Repetitive Sequences, Amino Acid
- Repetitive Sequences, Amino Acid/genetics