Reperfusion strategies in ST-elevation myocardial infarction--current status and perspectives for early and pre-hospital treatment.

Abstract

The latest guidelines on the emergency care of acute ST-elevation myocardial infarction were published by the European Resuscitation Council at the end of 2005. Since then, numerous studies have been presented, which have led to important conclusions. Among pharmacological interventions, the opinion on adjuncts to anticoagulant treatment in the area of thrombolysis as well as in primary coronary intervention seems to be moving away from unfractionated heparin towards low molecular weight heparin, and possibly even factor Xa-specific pentasaccharide or the direct antithrombin bivalirudin. Clopidogrel has developed to become an accepted standard alongside aspirin in thrombolytic therapy of ST-elevation myocardial infarction, even if some questions still remain open. The promising idea of "facilitated percutaneous coronary intervention" has shown itself to at least be problematic if performed immediately and routinely after thrombolysis; "rescue" intervention in the event of ineffective thrombolysis is, on the other hand, useful and effective. Apparently, a more individualistic approach is required, which combines new therapeutic options and patients' conditions on the one side with regional resources on the other, to produce an optimal and timely strategy, remembering that one size does not fit all.