Collapsing glomerulopathy: many means to a similar end.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18309347.
- Also identified by DOI 10.1038/sj.ki.5002742.
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Abstract
Collapsing glomerulopathy (CG) represents a morphologic pattern of disease, characterized histologically by glomerular capillary collapse, severe podocyte injury, and glomerular epithelial cell proliferation, and clinically by marked proteinuria and renal insufficiency. CG has multiple etiologies; however, many questions remain about its pathogenesis. A new set of animal models of CG, characterized by absence of the normal podocyte cytoskeletal protein alpha-actinin-4, has potential to help us gain a greater understanding of cellular events involved in producing this pattern of disease.
Medical subject headings
- Actinin
- Disease Models, Animal
- Glomerulonephritis
- Mice