Cannabinoids provoke alcoholic steatosis through a conspiracy of neighbors.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18316020.
- Also identified by DOI 10.1016/j.cmet.2008.02.002.
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Abstract
Cannabinoid signaling by CB1 receptors drives fibrogenesis and fat accumulation in liver. A report in this issue of Cell Metabolism (Jeong et al., 2008) now links hepatic stellate cells, a resident liver fibrogenic cell type, to the generation of steatosis through production of the endocannabinoid 2-arachidonoylglycerol (2-AG) after ethanol feeding, leading to paracrine stimulation of hepatocyte CB1 receptors.
Medical subject headings
- Cannabinoid Receptor Modulators
- Fatty Liver, Alcoholic
- Lipogenesis
- Liver
- Paracrine Communication
- Receptor, Cannabinoid, CB1