Muscle fatigue from losing your PHD.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18316022.
- Also identified by DOI 10.1016/j.cmet.2008.02.007.
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Abstract
Prolyl hydroxylases (PHDs) sense oxygen, regulate levels of hypoxia-inducible factors (HIFs), and permit hypoxic adaptation. A new study by Aragones et al. (2008) demonstrates that mice lacking skeletal muscle PHD1 have decreased exercise tolerance and oxygen consumption but remarkably tolerate ischemia in a HIF-2alpha- and PPARalpha-dependent fashion.
Medical subject headings
- Hypoxia
- Ischemia
- Muscle Fatigue
- Muscle, Skeletal
- Procollagen-Proline Dioxygenase