CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18316586.
- Also identified by DOI 10.1158/0008-5472.CAN-07-5983.
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Abstract
CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy.
Medical subject headings
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Neoplasms
- cdc25 Phosphatases