Atrial natriuretic factor after dopamine infusion in healthy subjects and in congestive heart failure.

Abstract

We evaluated the effects of dopamine (DA) infusion (1.5 micrograms.kg-1.min-1 for 60 min) on secretion of atrial natriuretic factor (ANF) in 10 healthy subjects and 10 patients with congestive heart failure (CHF) (NYHA Classes III and IV). During DA infusion plasma levels of ANF were significantly raised in healthy subjects while the high basal values of ANF in CHF patients were significantly reduced; this trend was also evident for plasma noradrenaline (NA) levels in both groups. Diuresis, natriuresis and glomerular filtration rate were significantly increased while blood pressure, heart rate and central venous pressure remained unchanged in both groups. These findings indicate that DA infusion may affect the release of ANF. Changes in plasma NA concentration suggest that the sympathetic nervous system may be involved in this phenomenon.