Hop1 and the meiotic DNA-damage response.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18329359.
- Also identified by DOI 10.1016/j.cell.2008.02.026.
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Abstract
During the DNA-damage response, adaptor proteins mediate signaling between the PI3K-like sensor kinases, ATM and ATR, and serine/threonine effector kinases. Carballo et al. (2008) now show that the chromosomal protein Hop1 mediates PI3K-like kinase signaling during the repair of DNA double-strand breaks (DSBs) in meiosis.
Medical subject headings
- DNA Repair
- DNA-Binding Proteins
- Meiosis
- Saccharomyces cerevisiae Proteins