Fluorescent magnetic nanohybrids as multimodal imaging agents for human epithelial cancer detection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18329706.
- Also identified by DOI 10.1016/j.biomaterials.2007.12.036.
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Abstract
Cetuximab conjugated fluorescent magnetic nanohybrids (CET-FMNHs) were synthesized for detection of human epithelial cancer via magnetic resonance (MR) and optical imaging. Spherical FMNHs consist of MnFe(2)O(4) magnetic nanocrystals encapsulated in pyrene-labeled PCL-b-PMAA as a surfactant prepared by a nano-emulsion method. FMNHs demonstrated excellent colloidal stability and biocompatibility for biomedical application. Antibody conjugated fluorescent magnetic nanohybrids (CET-FMNHs) served as effective agents for both magnetic resonance (MR) and fluorescence optical imaging of cancer cell lines.
Medical subject headings
- Antibodies, Monoclonal
- Epithelial Cells
- Fluorescent Dyes
- Nanoparticles