Middle cerebral artery occlusion in the rabbit using selective angiography: application for assessment of thrombolysis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18340097.
- Also identified by DOI 10.1161/STROKEAHA.107.507376 and PMC identifier 2443943.
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Abstract
An animal model of selective middle cerebral artery (MCA) occlusion is needed for evaluation of intra-arterial (IA) delivery of thrombolytic agents. We describe a technique for MCA thrombo-occlusion in the rabbit with real-time angiographic documentation of occlusion and thrombolytic recanalization. After femoral artery cutdown, a microcatheter was advanced from the internal carotid artery to the MCA. MCA occlusion was achieved by IA thrombin and reperfusion by IA plasmin. The terminal internal carotid artery was successfully catheterized in 12 of 13 animals. Stable (2-hour) MCA occlusion was induced and verified angiographically in all 12 animals; 2 animals also had distal internal carotid artery thrombus. Recanalization was achieved rapidly after IA plasmin in 3 of 3 animals. We describe a new animal model of selective MCA occlusion documented by real-time angiography and used to demonstrate recanalization with IA plasmin.
Medical subject headings
- Cerebral Angiography
- Infarction, Middle Cerebral Artery
- Intracranial Embolism
- Thrombolytic Therapy