Low oxygen stimulates the immune system.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18340350.
- Also identified by DOI 10.1038/ki.2008.15 and PMC identifier 3791324.
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Abstract
Changes in tissue oxygen levels trigger molecular signaling pathways that regulate cellular proliferation and differentiation in multiple cell types. The functional role of oxygen signaling in the immune system is not well understood. Rama and colleagues demonstrate that hypoxia induces dendritic-cell maturation; thus they provide a novel mechanistic link between hypoxia/ischemia and the activation of the immune system in the kidney.
Medical subject headings
- Cell Hypoxia
- Immune System