A quantitative analysis software tool for mass spectrometry-based proteomics.

Park, Sung Kyu; Venable, John D; Xu, Tao; Yates, John R · Nat Methods · 2008

basic_science · Level V

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Abstract

We describe Census, a quantitative software tool compatible with many labeling strategies as well as with label-free analyses, single-stage mass spectrometry (MS1) and tandem mass spectrometry (MS/MS) scans, and high- and low-resolution mass spectrometry data. Census uses robust algorithms to address poor-quality measurements and improve quantitative efficiency, and it can support several input file formats. We tested Census with stable-isotope labeling analyses as well as label-free analyses.

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