Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease.
Level II
Where this comes from
- Record sourced from PubMed, PMID 18356253.
- Also identified by DOI 10.1136/jnnp.2007.142380.
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Abstract
Two patients with moderate Huntington's disease (HD) received bilateral fetal striatal allografts. One patient demonstrated, for the first time, increased striatal D2 receptor binding, evident with 11C-raclopride positron emission tomography, and prolonged clinical improvement over 5 years, suggesting long term survival and efficacy of the graft. The other patient did not improve clinically or radiologically. Our results indicate that striatal transplantation in HD may be beneficial but further studies are needed to confirm this.
Medical subject headings
- Brain Tissue Transplantation
- Caudate Nucleus
- Corpus Striatum
- Fetal Tissue Transplantation
- Huntington Disease
- Positron-Emission Tomography
- Postoperative Complications
- Putamen