The Yin and Yang of treating BRCA-deficient tumors.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18358803.
- Also identified by DOI 10.1016/j.cell.2008.03.006.
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Abstract
The myriad changes that occur during the malignant progression of cancer cells present challenges to both clinicians and basic scientists. Two new studies in Nature underscore the central role of genome instability in tumor biology (Edwards et al., 2008; Sakai et al., 2008). These reports describe secondary changes in the BRCA2 locus that restore the wild-type reading frame and contribute to the development of resistance to chemotherapeutic agents.
Medical subject headings
- Breast Neoplasms
- Genes, BRCA2