Some vertebrates go with the GLO.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18358804.
- Also identified by DOI 10.1016/j.cell.2008.03.005.
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Abstract
Most vertebrates synthesize vitamin C (ascorbate) de novo from glucose, but humans and certain other mammals cannot. In this issue, Montel-Hagen et al. (2008) demonstrate that erythrocytes from these ascorbate auxotrophs switch the preference of their glucose transporter Glut1 from glucose to dehydroascorbate (DHA), the oxidized form of vitamin C. This substrate preference switch is mediated by the membrane protein stomatin and is an evolutionary adaptation to vitamin C deficiency.
Medical subject headings
- Dehydroascorbic Acid
- Glucose Transport Proteins, Facilitative