Transcription regulation through promoter-proximal pausing of RNA polymerase II.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18369138.
- Also identified by DOI 10.1126/science.1150843 and PMC identifier 2833332.
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Abstract
Recent work has shown that the RNA polymerase II enzyme pauses at a promoter-proximal site of many genes in Drosophila and mammals. This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation.
Medical subject headings
- Gene Expression Regulation
- Promoter Regions, Genetic
- RNA Polymerase II
- Transcription, Genetic