Gene regulation in the third dimension.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18369139.
- Also identified by DOI 10.1126/science.1152850 and PMC identifier 2666883.
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Abstract
Analysis of the spatial organization of chromosomes reveals complex three-dimensional networks of chromosomal interactions. These interactions affect gene expression at multiple levels, including long-range control by distant enhancers and repressors, coordinated expression of genes, and modification of epigenetic states. Major challenges now include deciphering the mechanisms by which loci come together and understanding the functional consequences of these often transient associations.
Medical subject headings
- Chromosomes
- Gene Expression Regulation