The first direct reprogramming of adult human fibroblasts.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18371396.
- Also identified by DOI 10.1016/j.stem.2007.11.013.
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Abstract
In recent issues of Cell and Science, Yamanaka and colleagues (Takahashi et al., 2007) and Yu and colleagues (Yu et al., 2007) demonstrate that expression of four specific transcription factors gives adult human fibroblasts many of the characteristics of human embryonic stem cells. Refinements of this procedure will make it possible to produce pluripotent human cell lines without use of an embryo. There are profound scientific and social implications of this research.
Medical subject headings
- Cellular Reprogramming
- Fibroblasts
- Genetic Techniques
- Pluripotent Stem Cells