Knocking the Wnt out of the sails of leukemia stem cell development.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18371398.
- Also identified by DOI 10.1016/j.stem.2007.11.006.
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Abstract
Tumor propagation by cancer stem cells (CSCs) requires their ability to self-renew, and yet the signal pathways involved in this process remain poorly defined. In the December issue of Cancer Cell, Zhao et al. (2007) provide compelling evidence that Wnt/beta-catenin signaling is crucial for the maintenance of chronic myelogenous leukemia (CML) stem cells.
Medical subject headings
- Leukemia
- Stem Cells
- Wnt Proteins
- beta Catenin