Thrombopoietin, HSCs, and the osteoblast niche: holding on loosely, but not letting G0.
review · Level V
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- Record sourced from PubMed, PMID 18371399.
- Also identified by DOI 10.1016/j.stem.2007.11.010.
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Abstract
New findings in this issue of Cell Stem Cell by Qian et al. (2007) and Yoshihara et al. (2007) reveal that thrombopoietin modulates hematopoietic stem cell (HSC) cell-cycle progression at the osteoblast surface, linking a single cytokine with a specific postnatal niche cell. These observations indicate that simultaneous stimulation and suspension in a G(0) state are critical for maintenance of the HSC pool.
Medical subject headings
- Hematopoietic Stem Cells
- Osteoblasts
- Resting Phase, Cell Cycle
- Thrombopoietin