Do cells let-7 determine stemness?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18371414.
- Also identified by DOI 10.1016/j.stem.2007.12.003.
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Abstract
During oncogenic transformation, microRNA levels of the translation-regulatory factor let-7 correlate inversely with expression of the HMGA2 oncoprotein. In a recent issue of Cell, Yu et al. (2007) now provide evidence that the let-7/HMGA2 linkage could be a signature of cancer stem cells in vivo, with broader implications for stem cell research.
Medical subject headings
- Gene Expression Regulation, Neoplastic
- HMGA2 Protein
- MicroRNAs
- Neoplastic Stem Cells