Germline stem cells: the first guards of heredity.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18371429.
- Also identified by DOI 10.1016/j.stem.2008.01.006.
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Abstract
The genes involved in the cellular response to DNA damage are crucial for ensuring DNA integrity during spermatogenesis. In this issue of Cell Stem Cell, Takubo et al. (2008) show that ATM, a key kinase of the DNA damage response, is also involved in maintaining the stem cell potential of undifferentiated spermatogonia.
Medical subject headings
- Cell Cycle Proteins
- DNA-Binding Proteins
- Heredity
- Protein Serine-Threonine Kinases
- Spermatogonia
- Stem Cells
- Tumor Suppressor Proteins