Foxa2: the rise and fall of dopamine neurons.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18371430.
- Also identified by DOI 10.1016/j.stem.2008.01.012.
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Abstract
Understanding the development and maintenance of dopamine neurons is essential to establish novel stem cell therapies and animal models of Parkinson's disease. A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa2(+/-) mice spontaneously develop Parkinsonism.
Medical subject headings
- Dopamine
- Hepatocyte Nuclear Factor 3-beta
- Neurons
- Parkinsonian Disorders