LIS1 and spindle orientation in neuroepithelial cells.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18371441.
- Also identified by DOI 10.1016/j.stem.2008.02.010.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.
Medical subject headings
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- Brain
- Cell Division
- Microtubule-Associated Proteins
- Neuroepithelial Cells
- Spindle Apparatus
- Stem Cells