MicroRNA regulation of stem cell fate.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18371442.
- Also identified by DOI 10.1016/j.stem.2008.02.008.
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Abstract
MicroRNAs modulate target gene expression and are essential for normal development, but how does this pathway impact cell fate decisions? In this issue of Cell Stem Cell, Ivey et al. (2008) find that muscle-specific microRNAs repress nonmuscle genes to direct embryonic stem cell differentiation to mesoderm and muscle.
Medical subject headings
- Cell Lineage
- Embryonic Stem Cells
- Gene Expression Regulation, Developmental
- Mesoderm
- MicroRNAs
- Myocardium
- Pluripotent Stem Cells