Therapeutic cloning in individual parkinsonian mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18376409.
- Also identified by DOI 10.1038/nm1732 and PMC identifier 2786166.
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Abstract
Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt)ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response.
Medical subject headings
- Embryonic Stem Cells
- Parkinsonian Disorders