Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 18378995.
- Also identified by DOI 10.1192/bjp.bp.107.046649.
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Abstract
Cannabis contains various cannabinoids, two of which have almost opposing actions: Delta9-tetrahydrocannabinol (Delta9-THC) is psychotomimetic, whereas cannabidiol (CBD) has antipsychotic effects. Hair samples were analysed to examine levels of Delta9-THC and CBD in 140 individuals. Three clear groups emerged: ;THC only', ;THC+CBD' and those with no cannabinoid in hair. The THC only group showed higher levels of positive schizophrenia-like symptoms compared with the no cannabinoid and THC+CBD groups, and higher levels of delusions compared with the no cannabinoid group. This provides evidence of the divergent properties of cannabinoids and has important implications for research into the link between cannabis use and psychosis.
Medical subject headings
- Cannabidiol
- Dronabinol
- Hair
- Marijuana Abuse
- Psychoses, Substance-Induced