Connecting the interpodocyte slit diaphragm and actin dynamics: Emerging role for the nephrin signaling complex.
Level V
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- Record sourced from PubMed, PMID 18379524.
- Also identified by DOI 10.1038/ki.2008.69.
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Abstract
Uchida et al. show in this issue that in rat and human nephrosis, tyrosine phosphorylation of nephrin is reduced, and this is accompanied by a decrease in F-actin in glomeruli. This, together with previous studies, suggests that the nephrin protein complex is a signaling nexus that regulates actin dynamics in podocytes.
Medical subject headings
- Actins
- Kidney Glomerulus
- Membrane Proteins
- Nephrosis
- Protein-Tyrosine Kinases