Predicting progression in primary progressive multiple sclerosis: a 10-year multicenter study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 18383506.
- Also identified by DOI 10.1002/ana.21375.
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Abstract
Rates of progression vary widely in primary progressive multiple sclerosis. This multicenter study aimed to identify predictors of progression over 10 years. A total of 101 patients who had been imaged at baseline and 2 years were scored on the expanded disability status scale after 10 years. Ordinal logistic regression identified the following independent variables that predicted progression: male sex, shorter disease duration, and slower timed walk test at baseline (best overall predictor), and deterioration in expanded disability status scale score and reduction in brain volume over 2 years. These predictors of long-term disability provide some insight into disease progression.
Medical subject headings
- Brain
- Disability Evaluation
- Multiple Sclerosis, Chronic Progressive
- Spinal Cord